"An apple a day keeps the doctor away from you" is a familiar proverb. But the best way to eat apples is to eat with your skin. According to the latest issue of Nature Medicine, U.S. researchers have found that the combination of dasartinib (a leukemia drug) and quercetin (an extract from Apple skin) can prolong the life span of elderly mice by 36%.
Aging cells usually appear in people in their 60s, but earlier in obese people or chronic disease patients. These abnormal cells are in decline, but they are not willing to die. Some people think that aging cells themselves will catalyze the aging process.
The research team led by James Kirkland at the Mayo Clinic in the United States proves that this is indeed the case. When the researchers injected small amounts of aging cells into six-month-old mice, their speed, endurance and strength dropped by 20 to 50 percent in a few weeks, roughly the level of a typical two-year-old mouse.
To block the effects of aging cells, the team chose a combination of dasartini and quercetin, which interfere with the way aging cells avoid death. When the team administered the combination of drugs to young mice aged by injecting aging cells, the mice regained their physical capacity by 50 to 100 percent within two weeks.
When the team administered the drug to mice aged 24 to 27 months, the mice increased their speed, endurance and strength by 30 to 100 percent, and their remaining life expectancy was 36 percent longer than those without it.
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