Although the medical community is still actively studying, there is no drug or drug combination that can effectively treat the most lethal skin cancer melanoma. Melanoma, also known as malignant melanoma, is a malignant tumor originates from melanocytes. It is common in the skin and also in the mucosa, eye and choroid. Melanoma is the most malignant tumor in skin tumors. It is easy to spread. Fortunately, a recent study has shown that vitamin B3 (nicotinic acid) may play an important role in the prevention and suppression of the disease.
The study was published in the journal dermatology, light immunology and light medicine by researchers from University of Sydney. The researchers found that vitamin B3 activity can prevent melanoma, and they also found nicotinamide, which can enhance the repair of DNA to respond to ultraviolet radiation. Melanoma begins in melanocytes, which produce melanin to protect the skin. Ultraviolet radiation exposure to sunlight is a known risk factor for melanoma, because it destroys the DNA of cells.
Diona Damian, one of the authors of the study, said nicotinamide refilled keratinocytes, that is, the energy stored in the skin cells of the epidermis, blocking a part of the sunlight. This enables them to repair DNA damage more effectively. In addition, nicotinamide alleviates inflammation, which is another risk factor for cancer. It plays an anti-inflammatory role by inhibiting the synthesis of inflammatory substances such as interleukin -6 and tumor necrosis factor Alfa. In addition, vitamin B3 helps reduce the immunosuppressive effect of sunlight on the skin.
The researchers also found that nicotinamide could inhibit vasculogenic mimicry. Vasculogenic mimicry makes the melanoma and other tumor cells form a tubular network, making it look like a normal venous network. It not only promotes tumor growth, but also leads to more malignant tumors.
Nicotinamide is also found to cause more melanoma cells to die, which weakens their spread and reproductive capacity. In addition, it can regulate the activity of sirtuin1, sirtuin1 is an enzyme related to the growth of cancer. Nicotinic acid also reduces the incidence of actinic keratosis, a precancerous hyperplasia that occurs when the body is exposed to sunlight.
In another study, researchers found that nicotinamide could prevent other skin cancers. In the study, the researchers recruited 386 participants, divided into two groups, to take 500 mg (mg) nicotinamide per day for one group of two times a year, and a group of equal doses of placebo.
The results showed that nicotinamide significantly reduced the incidence of two most common skin cancers, basal cell carcinoma and squamous cell carcinoma. The incidence of basal cell carcinoma decreased by 20%, while squamous cell carcinoma decreased by 30%. In addition, no adverse reactions occurred after taking nicotinamide.
Other health functions of vitamin B3
Vitamin B3 not only has a significant preventive effect on skin cancer, but also is beneficial to the health of all parts of the body. For example, digestion - vitamin B3 helps the normal function of the digestive system, promotes healthy appetite and skin health from outside.
Supports skin health - nicotinic acid helps protect skin from sunlight. It is also used as an anti aging cosmetic ingredient.
Reduce the symptoms of arthritis - vitamin B3 can enhance the flexibility of joints and fight inflammation caused by arthritis.
Reduce the risk of heart disease - nicotinic acid helps regulate cholesterol levels in the body. In addition, it also inhibits oxidative stress and inflammation, which is very helpful to the heart because it can harden arteries and block blood flow.
Support for mental health - nicotinic acid supplements are commonly used in the treatment of mental disorders such as anxiety, depression and bipolar disorder. Patients with depression are often lacking in nicotinic acid intake. (related studies: nicotinic acid and vitamin B3 can improve cognition and body function by preventing nerve injury).
Foods rich in nicotinic acid include fish, nuts, chicken, sugar beets, beer yeast, eggs, green vegetables and lean meat. Because nicotinic acid is a water-soluble vitamin, it can flow through human blood, and excess nicotinic acid can be excreted through urine. Therefore, nicotinic acid can be used as a solid or liquid form to facilitate consumers to consume daily.